Define handicap (noun) and get synonyms. What is handicap (noun)? handicap (noun) meaning, pronunciation and more by Macmillan Dictionary. a circumstance that makes progress or success difficult, Meaning, pronunciation, example sentences, and more from Oxford Dictionaries. A mental or physical disadvantage, such as blindness or a missing leg, is a handicap: something that disables you in some way. Handicaps can also be.